Personalised Multimodal Lifestyle Intervention as the Best-Evidenced Treatment for Chronic Pain

Context

To provide a clinical framework for simultaneously incorporating physical activity, stress, sleep and nutrition into a personalised multimodal lifestyle intervention for people with chronic pain. 

Methods

  • This publication was created using a narrative, expert‑driven synthesis of existing literature. 
  • The authors selected relevant literature on key lifestyle domains (exercise, sleep, stress, diet, weight management). 

They divided the paper into two main methodological components: 

  1. Guidance on how clinicians should design a personalised multimodal lifestyle intervention (assessment + behavioural change considerations). 
  2. A narrative synthesis summarising best‑evidence approaches for each lifestyle factor.

Results

  • Identify whether activities are being avoided or over‑done and match the strategy accordingly. 
  • Use graded or cognition‑targeted exercise for avoidance and activity pacing (with stress strategies if needed) for persistent/over‑done tasks. 
  • Routinely screen for insomnia, as it is a core driver of pain. 
  • Start with sleep education/hygiene and escalate to CBT‑insomnia when insomnia is significant or persistent. 
     
  • Recognise stress intolerance as a major amplifier of pain, fatigue and cognitive symptoms. 
  • Integrate stress education and provide/signpost practical coping techniques (relaxation, breathing, mindfulness, cognitive skills). 
     
  • Treat nutrition as a core treatment target, promoting whole‑food, anti‑inflammatory diets and addressing deficiencies. 
  • Support behavioural weight‑management where needed and pair dietary change with physical activity. 
     
  • Screen for smoking and alcohol, addressing them through motivational interviewing/signposting to reduce long‑term harm. 
  • Assess social connectedness and signpost supportive resources when low support contributes to pain and distress. 

Reference

Nijs, J. et al. (2024). Personalized Multimodal Lifestyle Intervention as the Best-Evidenced Treatment for Chronic Pain: State-of-the-Art Clinical Perspective. Journal of Clinical Medicine, 13(3), p.644.

23 March 2026

Copyright @ 2026 Rehab Direct - All Rights Reserved
Privacy Policy - Sitemap - Modern Slavery Statement

Rehab Direct
Privacy Overview

Rehabilitation Direct Limited (RD) understands that your privacy is important to you and that you care about how your personal data is used and shared online. We respect and value the privacy of everyone who visits this website, www.rehabdirect.co.uk and will only collect and use personal data in ways that are described here, and in a manner that is consistent with our obligations and your rights under the law. To read our full privacy policy, please Click Here.